团队负责人

柳志强，博士，教授，博士生导师，海南省BJ人才，主讲微生物学、微生物学实验、基因工程实验等课程。目前主要从事病原真菌致病机制及防控，热带微生物资源开发与利用等相关研究，先后主持国家自然科学基金3项，海南省重点研发计划1项，海南省自然科学基金2项，参与国家科技支撑计划、国家自然科学基金、农业农村部农产品风险评估项目等多项，在国内外期刊发表学术论文50余篇，其中SCI论文20余篇。

团队介绍

围绕危害动、植物及人类生命健康的重要病原真菌，系统研究病原真菌形态建成及致病相关基因的功能，解析相关次级代谢产物的合成机制，揭示其致病的分子机制，并针对病原真菌筛选有效的控制方法。本团队现有成员4人，其中教授2人，副研究员1人，实验师1人，海南省BJ人才2人。团队先后主持国家自然科学基金5项，海南省重点研发计划，高层次人才项目及海南省自然科学基金等多项，近5年发表SCI论文30余篇。

团队成员

李晓宇，张双飞，唐雯

主要研究方向

1、病原真菌分子致病机制及防控技术

2、病原真菌形态建成及调控机制

3、病原真菌次级代谢产物解析及调控机制

近期研究成果

[1] Jiujuan Zhao, Jinhua Sun, Min Li, Deqiang Gong, Jinyu Yang, Ying He, Zhiqiang Liu*, Meijiao Hu*. First report of anthracnose caused by Colletotrichum karstii on Dalbergia odorifera in China. Plant Disease, 2024, 108: 222.

[2] Jing Gao, Shuangzhen Zhou, Wen Tang, Jinhong Wang, Huanqing Liu, Ying Zhang, Liya Wang, Xiaoyu Li*, Zhiqiang Liu*. The velvet proteins CsVosA and CsVelB coordinate growth, cell wall integrity, sporulation, conidial viability and pathogenicity in the rubber anthracnose fungus Colletotrichum siamense. Microbiological Research, 2023, 268: 127290.

[3] Diguang Wang, Ying Zhang, Shuangzhen Zhou, Xingyuan Zhang, Shayu Liu, Xiaoyu Li*, Zhiqiang Liu*. Gcc1 homologs regulate growth, oxidative stress, conidiation and appressorium formation in Colletotrichum siamense and Colletotrichum graminicola. Microbial Pathogenesis, 2023, 182: 106249.

[4] Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu*, Jae-Hyuk Yu*. The putative C2H2 transcription factor VadH governs development, osmotic stress response, and sterigmatocystin production in Aspergillus nidulans. Cells, 2022, 11, 3998.

[5] Jinhong Wang, Rui Wang, Jing Gao, Huanqing Liu,  Wen Tang, Zhiqiang Liu, Xiaoyu Li*. Identification of three Streptomyces strains and their antifungal activity against the rubber anthracnose fungus Colletotrichum siamense. Journal of General Plant Pathology, 2023, 89: 67-76.

[6] Shumin Wang, Meijiao Hu, Xiangxiang Qu, Jinyu Yang, Zhaoyin Gao, Shuming Wang, Zhiqiang Liu*, Min Li*. First report of Colletotrichum queenslandicum causing leaf anthracnose on Dracaena cambodiana in China. Journal of General Plant Pathology, 2022, 88: 344-348.

[7] Xiaoyu Li, Zhijian Ke, Shuang Xu, Wen Tang , Zhiqiang Liu*. The G-protein alpha subunit CgGa1 mediates growth, sporulation, penetration and pathogenicity in Colletotrichum gloeosporioides. Microbial Pathogenesis, 2021, 161: 105254.

[8] Xiaoyu Li, Yateng Wu, Zhiqiang Liu*. Antifungal activity of an endophytic fungus Aspergillus versicolor DYSJ3 from Aphanamixis grandifolia Blume against Colletotrichum musae. Mycobiology, 2021, 49(5): 498-506.

[9] Xiaoyu Li, Shayu Liu, Nan Zhang, Zhiqiang Liu*. Function and transcriptome analysis of an oligopeptide transporter CgOPT2 in the rubber anthracnose fungus Colletotrichum gloeosporioides. Physiological and Molecular Plant Pathology, 2021, 115: 101661.

[10] Kai Zhang, Liushuang Gu, Yuefeng Zhang, Zhiqiang Liu*, Xiaoyu Li*. Dinactin from a new producer, Streptomyces badius gz-8, and its antifungal activity against the rubber anthracnose fungus Colletotrichum gloeosporioides. Microbiological Research, 2020, 240: 126548.

[11] Liushuang Gu, Kai Zhang, Nan Zhang, Xiaoyu Li*, Zhiqiang Liu*. Control of the rubber anthracnose fungus Colletotrichum gloeosporioides using culture filtrate extract from Streptomyces deccanensis QY-3. Antonie van Leeuwenhoek, 2020, 113: 1573-1585.

[12] Xiaoyu Li, Zhijian Ke, Xinjun Yu, Zhiqiang Liu*, Chenghui Zhang. Transcription factor CgAzf1 regulates melanin production, conidial development and infection in Colletotrichum gloeosporioides. Antonie van Leeuwenhoek, 2019: 112: 1095-1104.

主持科研项目

1. 柳志强，Homeobox型转录因子CgAfh1调控胶孢炭疽菌附着胞发育及侵染的分子机制，国家自然科学基金地区基金项目，2022/01-2025/12，34万元，项目编号：32160041

2. 李晓宇，橡胶炭疽病菌致病相关转录因子CgCon7的靶基因鉴定及调控机制，国家自然科学基金地区基金项目，2022/01-2025/12，35万元，项目编号：32160371

3. 李晓宇，暹罗炭疽菌Velvet蛋白CsVeA调控分生孢子发生及侵染的分子机制，海南省自然科学基金高层次人才项目，2024/03-2026/02，10万元，项目编号：324RC449

代表性成果介绍

1. 解析了暹罗炭疽菌Velvet蛋白CsVosA-CsVelB的调控功能及分子机制

2. 解析了构巢曲霉C2H2型转录因子VadH的生物学功能及调控机制