姓　名：黄小龙

职　称：副教授

导师类别：硕士生导师

E-mail：hxl2012@163.com

一、个人基本情况

姓名：黄小龙

职称：副教授 硕士研究生导师

邮箱：hxl2012@163.com

通讯地址：海南老员工命科学学院

邮政编码：570228

二、教育背景

2012/9 - 2014/8，中国海洋大学，医药学院，博士后。

2006/9 - 2009/6，永利集团，农业生物技术，博士。

2001/9 - 2004/6，湖南农业大学，生物化学与分子生物学，硕士。

1996/9 - 2000/6，湖南农业大学，园艺，学士。

三、教学情况

本科课程：微生物学、发酵工程、热带微生物资源开发与利用等。

研究生课程：现代微生物学专题、资源微生物学、微生物分类学。

研究生招收专业：生物学、生物与医药。

四、科研情况

主持或参与国家、省部级等科研课题24项，科研成果发表在Organic letters、Frontiers in Microbiology、Journal of Natural Products、Journal of Antibiotics、Marine Genomics、IJSEM等国内外杂志上，申请授权国家发明专利6项。获海南省科技进步三等奖1项，永利集团教学成果二等奖2项。

五、研究领域

主要从事热带海洋微生物资源分离、分类鉴定、天然产物的结构鉴定、微生物基因组与次级代谢产物挖掘，以及微生物功能菌株或活性天然产物在生物农药、微生物肥料、医药抗生素、抗肿瘤先导化合物等领域的应用研究。目前建立了2000多株的热带海洋微生物资源库，发表放线菌新种5个，完成了5株放线菌新种的全基因组测序，发现的活性天然产物有阿扎霉素、替达霉素、星形孢菌素、棘霉素、放线菌素D、烟曲霉酸和环肽等。

六、代表性科研项目

 

  1. 海南省重点研发计划项目，榴莲蜜种质资源鉴定、种苗培育及示范推广，ZDYF2022XDNY171，2022/03-2024/3，主持。

 2.教育部“春晖计划”合作科研项目，海绵共生放线菌中抗MRSA活性先导化合物的挖掘，RZ2000010713, 2020/01-2022/12，主持。

 3.海南省基础与应用基础研究计划（自然科学领域）高层次人才项目，基因组导向的海绵共附生放线菌中抗MRSA活性先导化合物的发掘，2019RC069，2020/01-2022/12，主持。

 4.海南省重点研发计划项目，热带海绵共生放线菌产抗肿瘤先导化合物吲哚咔唑生物碱研究，ZDYF2016125，2016/01-2017/12，主持。

 5.中国海洋大学海洋药物教育部重点实验室开放课题，海绵共生放线菌新种来源新型吲哚咔唑类生物碱的发现，KLMD（OUC）201403，2014/01-2016/12，主持。

 6.高等学校博士学科点专项科研基金联合资助项目，海南岛石珊瑚共附生放线菌多样性及其次生代谢产物研究，20124601120007，2013/01-2015/12，主持。

 7.973前期“热带药用植物及其共附生微生物中的抗肿瘤活性次生代谢产物的研究”，2007CB116306，参与。

 

 

七、代表性成果

 

SCI论文（*通讯作者；^#共同第一作者）

(1)Ji Zhu^#,Yuhui Xie^#, Yu Li, YuxinYang, ChenguiLi, Dongyi Huang, WenqiangWu, Yun Xu, Wei Xia, Xiaolong Huang*, Shuangqing Zhou*. Complete genome sequence of Streptomyces malaysiensis HNM0561, a marine sponge-associated actinomycete producing malaymycin and mccrearamycin E. Marine Genomics, 2022, 63: 100947.( SCI IF 1.76).

 

(2)Yuhui Xie^#, Lang Guo^#, Jie Huang^#, Xiaolong Huang* , Ziwen Cong, Qianqian Liu, Qianshu Wang, Xiaoyan Pang, Songtao Xiang, Xuefeng Zhou, Yonghong Liu,* Junjian Wang*, Junfeng Wang*.Cyclopentenone-containing tetrahydroquinoline and geldanamycin alkaloids from Streptomyces malaysiensis as potential anti-androgens against prostate cancer cells. Journal of Natural Products, 2021, 84(7):2004-2011.( SCI IF 4.05).

(3)Fenfa Li^#, Qingyi Xie^#, Shuangqing Zhou, Fandong Kong, Yun Xu, Qingyun Ma, Wenqiang Wu, Dongyi Huang, Youxing Zhao*, Xiaolong Huang*. Nocardiopsis coralli sp. nov. a novel actinobacterium isolated from the coral Galaxea astreata.  International Journal of Systematic and Evolutionary Microbiology, 2021,doi:10.1099/ijsem.0.004817.( SCI IF 2.74).

(4)Yuhui Xie, Shuangqing Zhou, Yun Xu, Wenqiang Wu, Wei Xia, Rongping Zhang, Dongyi Huang, Xiaolong Huang*, Gordonia mangrovi sp. nov., a novel actinobacterium isolated from mangrove soil in Hainan. International Journal of Systematic and Evolutionary Microbiology, 2020, 70(8): 4537-4543.( SCI IF 2.384).

(5) Mengmeng Song, Yuhui Xie, Weihao Chen, Yiwei Hu, Kai Zhao, Yonghong Liu, Xiaolong Huang*, Qingchao Liua*, Junfeng Wang*. Diketopiperazine and enterotoxin analogues from the mangrove derived-soil Streptomyces sp. SCSIO 41400 and their biological evaluation. Natural Product Research, 2020. doi:10.1080/14786419.2020.1864632.( SCI IF 2.158).

(6)Fandong Kong#, Shengliang Zhang#, Shuangqing Zhou, Qingyun Ma,Qingyi Xie, Jinping Chen, Jiuhui Li, Liman Zhou, Jingzhe Yuan, Zhong Hu, Haofu Dai, Xiaolong Huang*, Youxing Zhao*. Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114. Journal of Natural Products, 2019. doi:10.1021/acs.jnatprod.9b00845 ( SCI IF 4.257).

(7)Xiaolong Huang, Fandong Kong, Shuangqing Zhou, Dongyi Huang, Jiping Zheng, Weiming Zhu*. Streptomyces tirandamycinicus sp. nov., a novel marine sponge-derived actinobacterium with  potential against Streptococcus agalactiae. Frontiers in Microbiology, 2019. doi: 10.3389/fmicb.2019.00482 ( SCI IF 4.259).

(8)Wei Xia, Tingting Luo, Wei Zhang, Annaliese S. Mason, Dongyi Huang, Xiaolong Huang, Wenqi Tang, Yajing Dou, Chunyu Zhang, Yong Xiao*. Development of high-density SNP markers and their application in evaluating genetic diversity and population structure in Elaeis guineensis. Frontiers in Plant Science. 2019. doi: 10.3389/fpls.2019.00130. ( SCI IF 3.678).

(9)Shuangqing Zhou, Ke Xiao, Dongyi Huang, Wenqiang Wu, Yun Xu, Wei Xia, Xiaolong Huang*. Complete genome sequence of Streptomyces spongiicola HNM0071^T, a marine sponge-derived actinomycete producing staurosporine and echinomycin. Marine Genomics, 2019,43:61-64. (SCI IF 1.93)

(10)Ziwen Cong, Xiaolong Huang*, Yunhao Liu, Yuxuan Liu, Pei Wang, Shengrong Liao, Bin Yang, Xuefeng Zhou, Dongyi Huang, Junfeng Wang*. Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399. Journal of Antibiotics, 2019,72:45-49. ( SCI IF 2.033)

(11)Junfeng Wang, Ziwen Cong, Xiaolong Huang*, Chenxi Hou,Weihao Chen, Zhengchao Tu, Dongyi Huang, Yonghong Liu*. Soliseptide A, a cyclic hexapeptide possessing piperazic acid groups from Streptomyces solisilvae HNM30702.Organic letters, 2018, 20 (5):1371–1374.( SCI IF 6.49)

(12)Fandong Kong#, Xiaolong Huang#, Qingyun Ma, Qingyi Xie, Pei Wang, Pengwei Chen, Liman Zhou, Jingzhe Yuan, Haofu Dai, Duqiang Luo*, and Youxing Zhao*. Helvolic acid derivatives with potent anti-bacteria activities against Streptococcus agalactiae from the marine-derived fungus Aspergillus fumigatus HNMF0047. Journal of Natural Products, 2018, 81：869−1876. ( SCI IF 3.84)

(13)Shuangqing Zhou, Xiaobo Yang, Dongyi Huang, Xiaolong Huang*.Streptomyces solisilvae sp. nov., isolated from tropical forest soil. International journal of systematic and evolutionary microbiology, 2017, 67(9): 3553-3558. （SCI IF 1.93）

(14)Linya Liu, Yacheng Huang, Xiaolong Huang, Jianghua Yang , Wenqiang Wu, Yun Xu , Ziwen Cong , Jun Xie , Wei Xia, Dongyi Huang*. Characterization of the dioscorin gene family in Dioscorea alata reveals a role in tuber development and environmental response. International journal of molecular sciences, 2017, 18(7): 1579, doi:10.3390/ijms18071579. （SCI IF3.73）

(15)Xiaolong Huang, Shuangqing Zhou, Dongyi Huang, Jin Chen, Weiming Zhu*. Streptomyces spongiicola sp. nov., an actinomycete derived from marine sponge. International Journal of Systematic and Evolutionary Microbiology, 2016, 66(2): 738-743.（SCI IF 2.13）

(16)Junfeng Wang,Weijun He, Xiaolong Huang, Xinpeng Tian, Shengrong Liao,Bin Yang, Fazuo Wang, Xiaojiang Zhou, Yonghong Liu*. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879. Journal of agricultural and food chemistry, 2016, 64(14)：2910-2916.（SCI IF3.45）

(17)Fandong Kong，Chengying Zhao，Jiejie Hao，Cong Wang，Wei Wang，XiaoLong Huang，Weiming Zhu*. New α-glucosidase inhibitors from a marine sponge-derived fungus, Aspergillus sp. OUCMDZ-1583，RSC Advances，2015，5：68852-68863. （SCI IF3.06）

申请及授权发明专利

 

（1）黄小龙，周双清，黄东益，刘柱，郑继平，陶琳. 海绵共生链霉菌及其发酵生产星形孢菌素的方法和应用中国, CN20171107876.7, 2017.11.06

（2）王俊锋, 贺卫军, 黄小龙, 田新朋，刘永宏.抗生素Versicoloids A和B及其制备方法和在制备抗植物病原菌药物中的应用,中国,CN201710505896.2,2017.10.20

（3）周双清，黄小龙，周亚东，盛小彬，林旭俊，李晓斌，外源植物激素刺激降香黄檀结香的方法，2016.06.22，中国，ZL 201410104192.0

（4）周双清，黄小龙，周亚东，盛小彬，林旭俊，李晓斌，一种诱导降香黄檀结香的生物方法，2016.09.07，中国，ZL 201410104193.5

（5）黄小龙，周双清，黄东益，胡新文，一株山药内生利迪链霉菌DOR3-2及其应用，2013.11.27，中国，ZL201210255862.X

（6）洪葵，袁干军，林海鹏，谢晴宜，王成，黄小龙，唐依莉，新型阿扎霉F(Azalomycin F)类大环内酯化合物及其制备方法与应用，2013.03.09，中国，CN200910012396.